Meristem: Meeting Report: 2008 Banff Pork Seminar

The International Symposium on Chylomicrons in Disease (ISCD) 2008, with a theme to 'foster new frontiers', was hosted by the Alberta Institute for Human Nutrition (AIHN) and the University of Alberta. It brought together scientists covering the spectrum from basic discovery to clinical research, to share knowledge and drive progress on an emerging health frontier of fast-rising importance to the fight against heart disease, diabetes, obesity and other dietary-related chronic diseases.

The ISCD was held March 6-8 in Lake Louise, Alta. The agenda featured over 30 presentations and broad discussion of latest research, new opportunities and future challenges in this field. It also included presentations and awards focused on young investigators, helping to emphasize professional training and education at the international level. With sponsorship including the pharmaceutical and agricultural sectors, ISCD served as an important event for these two sectors to come together in the collective interest of highlighting the importance of nutrition in chronic disease.

ISCD is facilitating publication of Symposium proceedings in a major international journal (Atherosclerosis Supplement), expected to be in print by July of this year. Background information on ISCD and future information updates may be viewed at www.iscd2008.com.

The topic

Chylomicrons are large particles of dietary lipoproteins – essentially, balls of fat and cholesterol – that form in the small intestine following a meal. These chylomicron particles quickly absorb into the blood stream and are transported throughout the body, where they deliver a portion of their fat and cholesterol payload to various tissues. Research has indicated that the remaining chylomicron "remnants" form smaller lipoproteins, which can build up more quickly in arteries than any other type of cholesterol-carriers, including low-density-lipoproteins (LDL). In addition to heart disease, chylomicrons have been revealed as playing a major role in diabetes, obesity and other dietary-related chronic diseases.

The award

The ISCD Young Investigator Award for presentation is designed to acknowledge a young scientist demonstrating outstanding participation in and presentation of leading-edge research to advance knowledge in the area of chylomicrons.

The award is determined by an international judging panel of leading scientific experts in the field. Judges for the award included leading science authorities in the field. For example, judges notably included Dr. Jeffrey Cohn, Group Leader of Nutrition and Metabolism, University of Sydney in Australia; and Dr. Gerald Tomkin, Department of Diabetes and Endocrinology, Trinity College Dublin in Ireland.

Flora Wang was one of a handful of award finalists that spoke at the ISCD. Her presentation was part of a session on "nutrition and dietary impact on intestinal lipoprotein metabolism" that also included Dr. Denis Lairon, Director of Research for Human Nutrition and Lipids at INSERM-INRA (France); Dr. Jose Ordovas of Tufts University, Human Nutrition Research Centre (Massachusetts); Dr. Kathy Botham and Dr. Charlotte Lawson of the Royal Veterinary College in London; and Dr. Donna Vine of the Alberta Institute for Human Nutrition, University of Alberta.

The winner

Flora Wang is a PhD student in the Alberta Institute for Human Nutrition (AIHN), University of Alberta. Wang is pursuing her studies as part of the research team led by Dr. Spencer Proctor in the Metabolic and Cardiovascular Diseases Laboratory, AIHN, University of Alberta. The Laboratory has conducted numerous leading studies to explore the link between nutrition and the dietary-related chronic diseases such as cardiovascular disease, obesity and diabetes. This research has been pursued in part through Alberta government initiatives such as Agri-Health Initiative, designed to produce new discoveries and enhanced agriculture and food products to improve human health and wellness.

In addition to the ISCD Young Investigator Award, Wang previously earned an award for oral research presentation at the CLA Summit conference, themed "Harvesting the future," held in June 2007 in Kananaskis, Alta.

The sponsors

Major sponsors of ISCD 2008 included Merck Frosst / Schering Pharmaceuticals (Platinum), Pfizer Canada and Dairy Farmers of Canada (Silver) and several Bronze sponsors including Alberta Livestock Industry Development Fund, Merck Frosst, Canadian Society of Atherosclerosis Thrombosis and Vascular Biology, Bles-Wold Dairy Inc., CLA Network and the University of Alberta (including Faculty of Agricultural, Environmental & Life Sciences and Department of Agricultural, Food and Nutritional Science).

The Alberta / CLA connection

Researchers in the Metabolic and Cardiovascular Diseases Laboratory are members of the CLA Network – a team of researchers, food industry representatives, health professionals and communicators, devoted to progress with natural conjugated linoleic acid (CLA). CLA Network research has shown that natural TVA, which is a precursor to CLA, increases exponentially when natural CLA levels are increased in dairy products through practical dairy cattle feeding strategies.

These researchers have also been part of pioneering research around the world showing considerable human health and functional food potential for natural CLA. Alberta-based Bles-Wold Dairy Inc. recently commercialized a new yogurt and sour cream product line featuring substantial levels of natural CLA, based in part on research and assistance from the CLA Network.

Reprintable with credit. This article is available for reprint, with acknowledgement of the source: International Symposium on Chylomicrons in Disease (ISCD).

Communications Backgrounder

The topic

The award

The winner

The sponsors

The Alberta / CLA connection